OOCYTE DONATION

OOCYTE DONATION

Renew healthcare provides an Oocyte donation or egg donation program for a woman who cannot conceive with her own egg due to several factors. Egg donation or oocyte donation can help a woman to become a mother with the help of other women’s eggs. The clinic can recruit an egg donation program for couples to achieve parenthood.

Indication:

You can be considered for an egg donation program if Premature ovarian failure is the primary indication for use of Donor oocytes. The  secondary indications can be

  1. Premature menopause
  2. risk of passing a genetic disease
  3. Surgical oophorectomy
  4. if you are on Chemotherapy & Radiation therapy.
  5. repeated cycles of poor egg quality
  6. advanced Maternal age.

7..syndromes like  Gonadal dysgenesis, Turner’s syndrome, Fragile X syndrome

Screening of oocyte donors:

The donors can be selected by the clinician on the basis of age, ovarian reserve, and proven fertility of their own. Age is a dominant criterion; it is an independent prognostic factor of fertility outcome, preferably the donor’s age should it be between 21 to 30 years. The success of the treatment depends on the age of the Donor rather than the age of the recipient. The donor undergoes complete history and pelvic examinations and also undergoes certain tests.

The basic tests include

  • blood grouping,
  • complete blood count
  • all viral parameters screening
  • some hormonal tests AMH TSH, PROLACTIN etc,
  • Thalassemia testing,
  • transvaginal sonography to examine their ovary and follicle reserve.
  • Pap smear

Legal firms are also available that can recruit the oocyte donor for a couple. The donors always remain anonymous to the couple. Donors can also be screened for some Genetic tests if required but it is not included in routine testing. Once the donor is screened and selected proper documentation is the most essential step for any clinic.

Screening of recipients

Before recruiting the recipients for a donor program cycle, they are screened for routine blood  tests and hormonal tests to rule out thyroid, diabetes, or any pre-existing infection or disease   in addition to the routine tests an ECG and chest X-Ray is also prescribed.

If the age is more than 40, a Pap smear and transvaginal sonography is also added to assess their uterine cavity for any barriers in the way to successful embryo implantation. A diagnostic Hysteroscopy can be advised as a pre ivf test in some cases with a history of a previous implantation failure. Any structural defects or submucous fibroid can be rectified by a hysteroscopy.

If the Recipient is more than 45 years old, they need to undergo a thorough examination by a doctor for any pre-existing medical disorders like hypertension, Diabetes mellitus, heart disease, and kidney disease to rule out any risk in continuing the pregnancy if implantation is successful.

Procedure

It can be done in two ways.

Synchronization of the donor and the recipient– injections for ovarian stimulation on day 2 of the donor’s period the stimulation injection started and then monitored for follicular growth. Same time the recipient starts on estrogen tablets for making their endometrial lining. The moment the donor is ready for the pickup the recipient is synchronized by starting progesterone support after checking endometrial lining(>7mm) and after the donor’s ovum pick up the embryo is made with recipients partner’s sperm and then given on D3 morula stage or day 5 blastocyst stage.

IVF by donor oocyte followed by frozen embryo transfer– the donor is first simulated and pick up is completed, the embryo is made with recipient partner sperm making the embryos are stored in cryogen. When the recipient’s period comes endometrial lining is prepared either by hot cycle or by natural cycle and then when the endometrium is more than 7 mm vascularity in the endometrium is good then the progesterone support starts and embryos are transferred in the recipient’s uterus.

Responsibility of the clinic.

Written documentation for Donors, recipients, and their partners to keep them confidential and secure. It needs to be maintained for 10 years after reaching the records and should be transferred for maintenance by the ICMR.